Fig. 2
From: In vitro and in vivo characterization of the JAK1 selectivity of upadacitinib (ABT-494)
Preclinical efficacy of upadacitinib in rat adjuvant induced arthritis model. a Exposure–response relationships for upadacitinib (solid symbols) and tofacitinib (open symbols) in a rat adjuvant-induced arthritis model. b Quantitative effect of upadacitinib on bone erosion as assessed by micro CT scanning. c and d Representative micro CT scans of the tarsal regions of vehicle (c) and adjuvant-induced arthritis rats treated with upadacitinib (d)