Fig. 4
From: In vitro and in vivo characterization of the JAK1 selectivity of upadacitinib (ABT-494)
a Effect on reticulocyte inhibition compared with inhibition of paw swelling in rat AIA for tofacitinib (red circles) and upadacitinib (blue circles) Green arrows denote 60 and 80% inhibition of paw swelling. b Effect on NK cell inhibition compared with inhibition of paw swelling in rat AIA for tofacitinib (red circles) and upadacitinib (blue circles). Green arrows denote 60 and 80% inhibition of paw swelling. Individual animal values are graphed with 95% confidence intervals represented with black dotted lines