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Table 2 SSc mortality rates, SMR and hazard ratios

From: Trends in incidence, mortality, and causes of death associated with systemic sclerosis in Denmark between 1995 and 2015: a nationwide cohort study

 

1-year background mortality rate (per 100 PY)

1-year SSc mortality (no cases)

1-year SSc mortality rate (per 100 PY)

5-year SSc mortality (no cases)

5-mortality mortality rate (per 100 PY)

1-year SMR

1-year hazard ratio compared to background population (age and sex adjusted)

1995

1.23 (1.23–1.23)

8

6.1 (3.1–12.2)

19

3.1 (2.0–4.8)

5.0

5.3 (2.7–10.6)

1996

1.18 (1.17–1.19)

≤3

2.6 (0.8–8.1)

24

4.6 (3.1–6.8)

2.2

2.1 (0.7–6.4)

1997

1.16 (1.15–1.17)

9

8.7 (4.5–16.6)

24

4.9 (3.3–7.4)

7.5

8.3 (4.4–16.0)

1998

1.12 (1.11–1.13)

15

14.5 (8.8–24.1)

20

4.1 (2.6–6.3)

13.0

14.3 (8.6–23.7)

1999

1.13 (1.11–1.14)

8

5.3 (2.6–10.5)

28

4.0 (2.8–5.8)

4.7

5.2 (2.6–10.4)

2000

1.09 (1.08–1.10)

5

4.9 (2.1–11.9)

13

2.7 (1.6–4.7)

4.5

5.3 (2.2–12.6)

2001

1.10 (1.08–1.10)

9

10.5 (5.5–20.2)

23

6.1 (4.0–9.1)

9.6

9.6 (5.0–18.3)

2002

1.10 (1.09–1.10)

10

8.8 (4.8–16.4)

21

4.0 (2.6–6.1)

8.0

7.6 (4.1–14.1)

2003

1.07 (1.06–1.07)

8

6.7 (3.3–13.3)

27

5.0 (3.4–7.2)

6.3

6.5 (3.3–13.0)

2004

1.03 (1.02–1.03)

5

4.9 (2.0–11.8)

12

2.4 (1.4–4.3)

4.8

5.2 (2.2–12.4)

2005

1.00 (0.99–1.01)

7

6.0 (2.9–12.6)

26

4.9 (3.3–7.2)

6

5.6 (2.7–11.8)

2006

1.00 (1.00–1.01)

5

3.7 (1.5–8.9)

16

2.5 (1.5–4.0)

3.7

4.1 (1.7–9.8)

2007

1.00 (0.99–1.00)

7

5.1 (2.5–10.8)

18

2.8 (1.8–4.4)

5.1

6.2 (3.0–13.0)

2008

0.97 (0.96–0.98)

6

4.5 (2.0–10.0)

19

3.0 (1.9–4.7)

4.6

4.7 (2.1–10.4)

2009

0.97 (0.96–0.98)

11

8.1 (4.5–14.6)

23

3.6 (2.4–5.4)

8.4

8.2 (4.5–14.7)

2010

0.95 (0.94–0.96)

4

2.6 (1.0–7.0)

23

3.2 (2.1–4.8)

2.7

2.8 (1.1–7.4)

2011

0.91 (0.91–0.92)

12

7.2 (4.1–12.8)

25

3.2 (2.2–4.7)

7.9

8.9 (5.1–15.8)

2012

0.90 (0.89–0.91)

5

3.6 (1.6–9.5)

22

NA

4.0

4.8 (2.0–11.5)

2013

0.90 (0.89–0.91)

8

5.5 (2.7–11.0)

22

NA

6.1

6.0 (3.0–12.1)

2014

0.88 (0.87–0.89)

4

2.3 (0.9–6.2)

12

NA

2.6

3.0 (1.1–8.0)

2015

0.90 (0.89–9.90)

7

5.3 (2.5–6.2)

10

NA

5.9

5.6 (2.7–11.8)

Overall

1.02 (1.02–1.03)

NA

5.8 (5.0–6.8)

427

3.7 (3.3–4.1)

5.7

5.5 (4.7–6.4)

  1. Footnote: SMR denotes standardized mortality rate (i.e., mortality rate in SSc patients divided by mortality rate in background population). Mortality rates and hazard ratio are presented with 95% CIs