Table 1 Effect of intermittent fasting on transcriptome dysregulation in the collagen-induced arthritis model

Positive z-score

Retinol Biosynthesis

Ces4a (1.850), Lpl (1.520), Pnpla2 (1.900), Rdh11 (1.550)

Macrophage Alternative Activation Signaling Pathway

Cd36 (1.530), Il33 (-1.620), Il1r2 (2.070), Irs2 (1.690), Lpl (1.520), Retnla (-1.920), Tsc22d3 (2.230)

Nicotine Degradation II

Adh7 (2.110), Cyp2b10 (1.830), Fmo2 (2.920) Inmt (1.790)

Negative z-score

Systemic Lupus Erythematosus In B Cell Signaling Pathway

Cd72 (-1.510), Cd79a (-1.840), Ifna13 (-1.550), Ighv5-4 (-2.100), Ighv5-6 (-1.760), Ighv5-15 (-2.100), Ighv8-9 (-1.970), Ighv8-13 (-1.840), Igkv12-89 (-1.900), Igkv13-84 (-1.770), Igkv6-23 (-1.590), Igkv7-33 (-1.840), Igkv8-16 (-1.500), Igkv9-123 (-1.620), Il33 (-1.620), Rasd1 (1.510)

Osteoarthritis Pathway

Bglap2 (-1.850), Casq1 (-1.710), Ddit4 (3.150), Il1r2 (2.070), Itgb6 (-1.700), Sdc4 (1.720)

No activity available pattern

Altered T Cell and B Cell Signaling in Rheumatoid Arthritis

Cd79a (-1.840), Ighv5-4 (-2.100), Ighv5-6 (-1.760), Ighv5-15 (-2.100), Ighv8-9 (-1.970), Ighv8-13 (-1.840), Igkv12-89 (-1.900), Igkv13-84 (-17-127 (-1.770), Igkv6-23 (-1.590), Igkv7-33 (-1.840), Igkv8-16 (-1.500), Igkv9-123 (-1.620), IL33 (-1.620), Traj29 (-1.600), Trav11d (-1.500), Trav7d-2 (-1.500)

Phospholipase C Signaling

Cd79a (-1.840), Ighv5-4 (-2.100), Ighv5-15 (-2.100), Ighv8-9 (-1.970), Ighv8-13 (-1.840), Igkv12-89 (-1.900), Igkv13-84 (-17-127 (-1.770), Igkv6-23 (-1.590), Igkv7-33 (-1.840), Igkv8-16 (-1.500), Igkv9-123 (-1.620), Itgb6 (-1.700), Plcd4 (-1.580), Rasd1 (1.510), Rhou (1.750), Traj29 (-1.600), Trav11d (-1.500), Trav7d-2 (-1.500)