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Table 4 Effect of TAC with MMF or CYC on the complete response in SLE patients

From: Effect of tacrolimus with mycophenolate mofetil or cyclophosphamide on the renal response in systemic lupus erythematosus patients

TAC/CYC/MMF

Non-CR, n (%)

CR, n (%)

OR

(95% CI)

Adjusted OR

(95% CI)

CYC as reference

 CYC

258(75.7)

83(24.3)

1.00

1.00

 TAC

51(58.6)

36(41.4)

1.72(1.04,2.85)

1.97(1.10,3.53)

 TAC + CYC

43(65.2)

23(34.8)

2.02(1.16,3.51)

2.15(1.15,4.02)

 TAC + MMF

26(53.1)

23(46.9)

2.75(1.49,5.08)

2.43(1.20,4.92)

 TAC + MMF + CYC

21(50.0)

21(50.0)

3.11(1.62,5.98)

2.69(1.33,5.45)

  P TAC*CYC

  

0.038

0.043

MMF as reference

 MMF

101(77.7)

29(22.3)

1.00

1.00

 TAC

51(58.6)

36(41.4)

2.46(1.36,4.45)

2.89(1.50,5.58)

 TAC + MMF

26(53.1)

23(46.9)

3.08(1.54,6.18)

3.54(1.66,7.58)

 TAC + CYC

43(65.2)

23(34.8)

1.86(0.97,3.58)

3.14(1.49,6.64)

 TAC + MMF + CYC

21(50.0)

21(50.0)

3.48(1.67,7.24)

3.94(1.74,8.95)

  P TAC*MMF

  

0.013

0.025

  1. The confounding factors in the multivariate regression analysis were sex (female = 1, male = 0), age (continuous), SLE disease period (continuous), comorbidities (yes = 1, no = 0), SLEDAI score (continuous), abnormal urinary protein (yes = 1, no = 0), abnormal serum creatinine (yes = 1, no = 0), renal-protective agents (yes = 1, no = 0), HCQ treatment (yes = 1, no = 0), GCs dose (continuous) and other immunosuppressants (yes = 1, no = 0). PTAC*CYC is P for the synergy between TAC and CYC. PTAC*MMF is P for the synergy between TAC and MMF