Skip to main content

Table 2 Crude incidence rate, and cox proportional hazard analysis for psoriasis

From: The role of C-reactive protein and genetic predisposition in the risk of psoriasis: results from a national prospective cohort

 

Event, n (%)

IR (95% CI)

per 1000 person-years

Adjusted HR

(95% CI)

P Value

PAF (%)

(95% CI)

CRP

     

Log-CRP per 1-SD increase

4160/420,040 (0.99%)

0.81 (0.78, 0.83)

1.16 (1.12, 1.20)

< 0.0001

-

< 2 mg/dL

2327/273,012 (0.85%)

0.69 (0.66, 0.72)

Reference

 

Reference

≥ 2 mg/dL

1833/147,028 (1.25%)

1.03 (0.98, 1.08)

1.26 (1.18, 1.34)

< 0.0001

7.65 (5.70, 9.60)

Q1

748/103,526 (0.72%)

0.58 (0.54, 0.62)

Reference

 

Reference

Q2

933/106,014 (0.88%)

0.71 (0.67, 0.76)

1.11 (1.01, 1.22)

0.0355

2.00 (0.28, 3.72)

Q3

1106/105,216 (1.05%)

0.86 (0.81, 0.91)

1.24 (1.13, 1.37)

< 0.0001

4.57 (2.74, 6.40)

Q4

1373/105,284 (1.30%)

1.08 (1.02, 1.14)

1.45 (1.31, 1.59)

< 0.0001

8.68 (6.37, 11.00)

   

P-trend < 0.0001

  

PRS

     

Per 1 score increase

4160/420,040 (0.99%)

0.81 (0.78, 0.83)

1.32 (1.29, 1.36)

< 0.0001

-

[0%, 33.3%]

999/139,876 (0.71%)

0.58 (0.55, 0.62)

Reference

 

Reference

(33.3%, 66.6%]

1291/139,870 (0.92%)

0.75 (0.71, 0.79)

1.29 (1.19, 1.40)

< 0.0001

6.64 (4.63, 8.65)

(66.6%, 100%]

1870/140,294 (1.33%)

1.09 (1.04, 1.14)

1.87 (1.73, 2.02)

< 0.0001

19.97 (17.56, 22.39)

   

P-trend < 0.0001

  
  1. CRP, C-reactive protein; PRS: polygenic risk score; IR, incidence rate; CI, confidence interval; HR, hazard ratio; PAF, population attributable fraction
  2. Adjustment for age, sex, ethnicity, annual income, smoking status, drinking status, Body mass index (BMI), diabetes mellitus, dyslipidemia, and hypertension history