Outcomes | PRS levels (HR, 95% CI) | | RERI ‡ | P for interaction § |
|---|
Low PRS | Moderate PRS | High PRS | | Moderate PRS | High PRS |
|---|
CRP | | | | | | | |
< 2 mg/dL | 1.00 | 1.16 (1.04, 1.29) | 1.68 (1.52, 1.86) | | | | 0.0028 |
≥ 2 mg/dL | 1.04 (0.91, 1.18) | 1.55 (1.38, 1.74) | 2.24 (2.01, 2.49) | | 0.37 (0.17, 0.56) | 0.51 (0.30, 0.73) | |
- Adjustment for age, sex, ethnicity, annual income, smoking status, drinking status, Body mass index (BMI), diabetes mellitus, dyslipidemia, and hypertension history
- HR, hazard ratio; CI, confidence interval; CRP, C-reactive protein; PRS: polygenic risk score; RERI, relative excess risk due to interaction
- ‡: The estimates of RERI were calculated based on the reference group with low CRP and low PRS
- §: Likelihood tests was applied to test the significance of interaction term by comparing the model with and without the interaction term
