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Table 2 Interaction effect between RDW and PRS with incident RA on the multiplicative and additive scale

From: Association between red blood cell distribution width and genetic risk in patients with rheumatoid arthritis: a prospective cohort study and Mendelian randomization analysis

RDW

PRS

RERI

AP

S

Multiplicative effect

Pint

Q1

Low

0

0

1

1

-

Q2

Intermediate

−0.43 (−1.78, 0.92)

−0.23 (−0.92, 0.45)

0.66 (0.25, 1.71)

0.69 (0.28, 1.67)

0.411

Q2

High

0.30 (−1.38, 1.98)

0.10 (−0.45, 0.64)

1.17 (0.45, 3.04)

0.89 (0.34,2.33)

0.806

Q3

Intermediate

−0.49 (−1.81, 0.84)

−0.29 (−0.99, 0.42)

0.59 (0.22, 1.55)

0.68 (0.28, 1.64)

0.390

Q3

High

1.24 (−0.46, 2.93)

0.31 (−0.08, 0.71)

1.71 (0.67, 4.37)

1.21 (0.47, 3.11)

0.688

Q4

Intermediate

1.77 (0.63, 2.92)

0.48 (0.19, 0.77)

2.88 (0.71, 11.70)

1.79 (0.74, 4.34)

0.199

Q4

High

5.38 (1.90, 8.86)

0.67 (0.49, 0.86)

4.32 (1.53, 12.19)

2.76 (1.07, 7.14)

0.036

  1. RERI relative excess risk due to interaction, AP attributable proportion due to interaction, S synergy index