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Table 2 Fully adjusted multivariable Cox proportional hazards model for association between use of DMARDs and incident multiple myeloma in rheumatoid arthritis

From: Use of disease modifying anti-rheumatic drugs and risk of multiple myeloma in US Veterans with rheumatoid arthritis

Clinical characteristic

Adjusted hazard ratio (95% CI)

b/tsDMARD use

1.32

(0.78, 2.26)

Age*

1.04

(1.01, 1.07)

Female

0.58

(0.20, 1.66)

Race

  

 Black

2.17

(1.20, 3.95)

 Other

0.76

(0.10, 5.46)

Ethnicity

  

 Hispanic or Latino

0.7

(0.16, 3.03)

Current smoker

0.82

(0.43, 1.58)

BMI < = 18.5

0

(0.00, Inf)

BMI > 30

1.72

(0.78, 3.80)

BMI 25–30

1.7

(0.81, 3.59)

Baseline CRP 3–30

1.07

(0.50, 2.27)

Baseline CRP 30–50

2.19

(0.84, 5.76)

Baseline CRP 50+

1.61

(0.64, 4.04)

Steroid use in year prior

1.64

(1.03, 2.59)

Baseline RDCI1

0.43

(0.20, 0.96)

Baseline RDCI2

0.88

(0.46, 1.70)

Baseline RDCI3

0.91

(0.43, 1.90)

Baseline RDCI4+

1.02

(0.48, 2.15)

  1. Model adjusted for age, sex, race, ethnicity, smoking status, BMI, CRP (in mg/l), cohort entry, steroid use in prior year, baseline RDCI
  2. Abbreviations bDMARD biologic disease modifying anti-rheumatic drug, BMI body mass index, CRP C-reactive protein, RDCI rheumatic disease comorbidity index
  3. *Hazards ratio reflects risk per every 1-year increase in age