Medication | 2017 | 2018 | 2019 | 2020 | 2021 | |||||
---|---|---|---|---|---|---|---|---|---|---|
n* | %** | n* | %** | n* | %** | n* | %** | n* | %** | |
csDMARDs | 37,059 | 39.23 | 38,979 | 36.18 | 50,834 | 36.98 | 31,951 | 26.98 | 39,711 | 28.61 |
Chloroquine | 12,298 | 13.02 | 12,425 | 11.53 | 14,122 | 10.27 | 8,309 | 7.02 | 11,451 | 8.25 |
Hydroxychloroquine | 1,897 | 2.01 | 2,153 | 2.00 | 2,929 | 2.13 | 3,879 | 3.28 | 4,401 | 3.17 |
Leflunomide | 16,846 | 17.83 | 18,710 | 17.37 | 23,629 | 17.19 | 15,450 | 13.05 | 17,224 | 12.41 |
Methotrexate | 3,491 | 3.70 | 3,374 | 3.13 | 6,492 | 4.72 | 2,949 | 2.49 | 5,256 | 3.79 |
Sulfasalazine | 2,527 | 2.67 | 2,317 | 2.15 | 3,662 | 2.66 | 1,364 | 1.15 | 1,379 | 0.99 |
bDMARDs | 5,733 | 6.07 | 5,829 | 5.41 | 7,055 | 5.13 | 4,612 | 3.89 | 5,170 | 3.72 |
Abatacept | 186 | 0.20 | 120 | 0.11 | 129 | 0.09 | 135 | 0.11 | 0 | 0.00 |
Adalimumab | 1,031 | 1.09 | 929 | 0.86 | 1,593 | 1.16 | 517 | 0.44 | 1,080 | 0.78 |
Certolizumab pegol | 217 | 0.23 | 86 | 0.08 | 162 | 0.12 | 181 | 0.15 | 126 | 0.09 |
Etanercept | 2,147 | 2.27 | 2,332 | 2.16 | 2,381 | 1.73 | 1,651 | 1.39 | 1,582 | 1.14 |
Golimumab | 59 | 0.06 | 38 | 0.04 | 48 | 0.03 | 70 | 0.06 | 46 | 0.03 |
Infliximab | 138 | 0.15 | 127 | 0.12 | 163 | 0.12 | 132 | 0.11 | 163 | 0.12 |
Rituximab | 923 | 0.98 | 1,127 | 1.05 | 1,450 | 1.05 | 1,117 | 0.94 | 1,243 | 0.90 |
Tocilizumab | 1,032 | 1.09 | 1,070 | 0.99 | 1,129 | 0.82 | 809 | 0.68 | 930 | 0.67 |
tsDMARDs | 859 | 0.91 | 1,163 | 1.08 | 1,579 | 1.15 | 1,925 | 1.63 | 2,488 | 1.79 |
Baricitinib | 0 | 0.00 | 0 | 0.00 | 19 | 0.01 | 204 | 0.17 | 530 | 0.38 |
Tofacitinib | 859 | 0.91 | 1,163 | 1.08 | 1,560 | 1.13 | 1,721 | 1.45 | 1,957 | 1.41 |
Upadacitinib | 0 | 0.00 | 0 | 0.00 | 0 | 0.00 | 0 | 0.00 | 1 | 0.00 |
Glucocorticoids | 54,474 | 57.66 | 25,394 | 23.57 | 63,201 | 45.97 | 33,898 | 28.62 | 67,774 | 48.83 |
Deflazacort | 2,864 | 3.03 | 3,083 | 2.86 | 3,214 | 2.34 | 3,292 | 2.78 | 3,345 | 2.41 |
Dexamethasone | 2,286 | 2.42 | 2,443 | 2.27 | 2,268 | 1.65 | 1,178 | 0.99 | 6,934 | 5.00 |
Hydrocortisone | 450 | 0.48 | 534 | 0.50 | 565 | 0.41 | 297 | 0.25 | 190 | 0.14 |
Methylprednisolone | 956 | 1.01 | 1,108 | 1.03 | 1,286 | 0.94 | 1,656 | 1.40 | 3,121 | 2.25 |
Prednisolone | 47,918 | 50.72 | 18,226 | 16.92 | 55,868 | 40.64 | 27,475 | 23.20 | 54,184 | 39.04 |
Prednisone | 2,846 | 3.01 | 961 | 0.89 | 714 | 0.52 | 395 | 0.33 | 343 | 0.25 |