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Table 2 Anthropometric, clinical and biochemical characteristics o patients with diffuse SSc and limited SSc

From: Are the clinical phenotypes of systemic sclerosis determinant for osteoporosis and fragility fractures?

 

Diffuse SSc (N = 43)

Limited SSc (N = 41)

Age (years)a

64.8 ± 12.5

62.4 ± 15.1

Gender (F/M)b

40/3

37/4

BMI (Kg/m2)a

24.9 ± 5.5

24.1 ± 5.1

Menopause (years)a

51.5 ± 2.8

52.3 ± 2.5

Disease duration (years)a

14.4 ± 7.9

13.2 ± 8.1

Creatinine (mg/dl)a

0.78 ± 0.19

0.82 ± 0.15

Albumina (mg/dl)a

3.6 ± 0.7

3.8 ± 0.6

Calcium (mg/dl)a

9.46 ± 0.66

9.26 ± 0.56

Phosphate (mg/dl)a

3.56 ± 0.45

3.72 ± 0.63

ALP (UI/L)a

67.82 ± 21.96

73.17 ± 25.85

B-ALP (µg/l)a

11.27 ± 4.81

12.97 ± 7.86

25OHD (ng/ml)a

21.42 ± 15.17

24.66 ± 13.59

PTH (pg/ml)a

43.76 ± 11.92

41.37 ± 18.62

mRSS scorea

17.1 ± 7.9

6.3 ± 2.8**

ANA positive, n/total (%)

41/43(95%)

40/41 (97%)

Anti-Scl-70, n/total (%)

13/43 (30%)

6/41 (15%)

Anti-centromere, n/total (%)

7/43 (16%)

25/41 (61%)**

DLCO (%)a

67.10 ± 18.56

72.59 ± 20.91*

Organ manifestation

  

Interstitial lung disease, n/total (%)b

33/43 (77%)

22/41 (54%)*

Pulmonary hypertension, n/total (%)b

8/43 (18%)

4/41 (10%)

Digital ulcerations, n/total (%)b

7/43 (16%)

3/41 (7%)

Esophageal atony, n/total (%)b

20/43 (46%)

16/41 (39%)

  1. Abbreviation SSc: Systemic sclerosis; F: female; M: male; BMI: body mass index; ALP: alkaline phosphatase; B-ALP: bone alkaline phosphatase; 25OHD: 25-hydroxyvitam D; PTH: intact parathyroid hormone; mRSS: modified Rodnan skin score; ANA: antinuclear antibody; Anti-Scl-70: anti-topoisomerase I; DLCO: diffusion capacity for carbon monoxide
  2. *p < 0.05 **p < 0.001 Diffuse SSc vs. Limited SSc
  3. aStudent’s T test
  4. bDichotomous variable, reference NO (chi-square Yates corrected test)