Table 3 Solid organ neoplasm-related deaths differences between SSc patients and the general Spanish population by lineage

Solid organ neoplasm

127,091 (91.1)

62 (92.5)

0.832

1.292 (0.519-3.221)

Malign solid organ neoplasm

124,841 (89.5)

62 (92.5)

0.550

1.548 (0.621-3.860)

 Digestive system

41,580 (29.8)

11 (16.4)

0.019

0.509 (0.266-0.977)

  Esophagus

2,319 (1.7)

2 (3)

0.307

3.054 (0.742-12.577)

  Stomach

6,426 (4.6)

3 (4.5)

1

1.031 (0.324-3.286)

  Small bowel

459 (0.3)

0

1

-

  Colo-rectal

15,059 (10.8)

4 (6)

0.241

0.583 (0.211-1.611)

  HCC and others

3.817 (2.7)

0

1

-

  Pancreas

8.709 (6.2)

2 (3)

0.443

0.413 (0.101-1.684)

  Cholangiocarcinoma

4.485 (3.2)

0

0.281

-

 Lung

25,886 (18.6)

17 (25.4)

0.157

2.228 (1.260-3.937)

 Breast

3,631 (2.6)

1 (1.5)

1

0.256 (0.035-1.852)

 Gynecological

4,130 (3.0)

9 (13.4)

<0.001

4.804 (2.372-9.730)

  Vulva

280 (0.2)

1 (1.5)

0.126

8.325 (1.145-60.510)

  Vagina

63 (0.1)

0

1

-

  Cervix

649 (0.5)

2 (3)

0.039

2.937 (0.710-12.149)

  Uterine

1,261 (0.9)

3 (4.5)

0.014

6.177 (1.931-19.758)

  Ovarian

1.746 (1.3)

3 (4.5)

0.052

3.456 (1.083-11.032)

  Other

131 (0.1)

0

1

-

 Otorhinolaryngological

4.107 (2.9)

2 (3)

1

1.557 (0.379-6.398)

 Endocrine

1,780 (1.3)

2 (3)

0.211

2.165 (0.529-8.865)

 Neuroendocrine

1,289 (0.9)

2 (3.2)

0.135

3.202 (0.780-13.146)

 Skin

1,025 (0.7)

1 (1.5)

0.390

2.174 (0.301-15.707)

  Melanoma

532 (0.4)

0

1

-

 Central nervous system

4,029 (2.9)

2 (3.2)

0.720

0.932 (0.226-3.833)

 Urological

11,072 (7.9)

2 (3)

0.173

0.703 (0.169-2.920)

  Prostate

3,290 (2.4)

0

0.412

-

  Kidney

2,138 (1.5)

0

0.629

-

  Bladder

5,147 (3.7)

2 (3)

1

1.507 (0.364-6.242)

  Others

497 (0.4)

0

1

-

 Others

4,212 (3.0)

4 (6)

0.144

1.874 (0.681-5.154)

 MUO

23,390 (16.8)

11 (16.4)

1

0.774 (0.404-1.483)

BSON

727 (0.5)

0

0.596

-

UBSON

1,327 (1.0)

0

1

-

Carcinoma in situ

187 (9.1)

0

1

-