Table 2 Factors associated with each domain of quality of life among SLE patients

Cognitive Impairment^*

 Yes

80.35 (65.67–85.83)

0.750

81.20 (68.75–90.62)

0.200

83.3 (66.60–91.60)

0.500

83.3 (75–100)

0.120

100 (75–100)

0.890

75 (50–91.60)

0.410

79.10 (54.10–87.50)

0.730

85 (50–100)

0.880

75 (56.25–87.50)

0.810

 No

77.25 (65.42–88.48)

78.10 (68.72–85.83)

75 (67.65–87.45)

91.66 (75–100)

100 (75–100)

75 (50–91.60)

75 (62.50–91.63)

80 (70–94)

75 (56.25–87.50)

Anxiety^*

 Yes

65.33 (50.77–77.18)

< 0.001^***

70.27 (62.50–80.42)

< 0.001^***

75 (52.07–83.30)

< 0.001^***

75 (58.30–91.60)

< 0.001^***

75 (56.25–100)

0.001^***

50 (27.07–75)

< 0.001^***

58.3 (37.50–75)

< 0.001^***

72.5 (46.25–85)

< 0.001^***

62.25 (89.06–75)

< 0.001^***

 No

84.20 (76.85–89.24)

84.37 (75–90.62)

83.30 (75–91.82)

91.66 (83.30–100)

100 (87.35–100)

83.3 (75–98.67)

83.3 (75–93.30)

90 (75–100)

75 (62.50–87.50)

Depression^*

 Yes

63.22 (47.02–83.74)

0.003^***

70.27 (52.34–80.42)

0.008^***

70.8 (41.60–89.52)

0.013^***

75 (54.15–91.60)

0.004^***

75 (40.62–100)

0.003^***

50 (27.07–81.22)

0.007^***

60.4 (34.45–86.50)

0.021^***

72.5 (28.75–93.75)

0.041^***

68.75 (40.62–87.50)

0.373

 No

81.06 (71.11–87.20)

82.22 (69.51–90.60)

75 (75–91.60)

91.6 (75–100)

100 (75–100)

75 (58.30–91.64)

79.16 (70.80–90.57)

85 (70–100)

75 (62.12–81.62)

Disease duration^**

r 0.24

0.011^***

r 0.14

0.132

r 0.11

0.249

r 0.10

0.298

r 0.12

0.249

r 0.24

0.011^***

r 0.28

0.003^***

r 0.20

0.034^***

r 0.25

0.070

Age^**

r 0.18

0.058

r 0.22

0.018^***

r 0.12

0.196

r 0.03

0.752

r –0.19

0.043^***

r 0.37

< 0.001^***

r 0.29

0.002^***

r 0.19

0.045^***

r 0.19

0.042^***

Disease activity^**

r -0.15

0.117

r -0.10

0.266

r -0.10

0.299

r -0.08

0.378

r 0.07

0.427

r -0.13

0.160

r -0.22

0.016^***

r -0.18

0.060

r -0.21

0.022^***

Comorbidities^*

 Yes

81.51 (62.44–88)

0.680

78.10 (75–91.60)

0.731

75 (58.30–91.60)

0.342

83.30 (75–100)

0.691

100 (75–100)

0.468

75 (54.15–93.20)

0.133

83.30 (54.15–91.68)

0.377

90 (75–100)

0.210

75 (56.22–87.50)

0.807

 No

77.99 (65.67–86.75)

78.10 (68.70–87.50)

75 (75–91.60)

91.60 (75–100)

100 (75–100)

75 (41.60–83.30)

75 (62.50–87.50)

80 (65–95)

75 (56.25–87.50)

Steroid dose^**

r -0.10

0.291

r -0.06

0.541

r -0.11

0.236

r -0.12

0.213

r 0.04

0.710

r -0.09

0.332

r -0.15

0.102

r -0.18

0.051

r -0.14

0.120

Immunosuppressant medication^*

Hydroxychloroquine

 Yes

80.86 (65.40–86.75)

0.790

78.12 (68.75–90.60)

0.671

75 (66.60–91.60)

0.878

83.70 (75–100)

0.711

100 (75–100)

0.682

75 (41.60–91.60)

0.860

75 (41.60–91.60)

0.447

80 (65–100)

0.530

70 (56.25–87.50)

0.386

 No

78.16 (69.56–87.76)

78.10 (68.75–87.50)

75 (75–87.45)

91.60 (75–100)

100 (75–100)

75 (50.36–91.60)

75 (50.36–91.60)

85 (75–95)

75 (62.50–87.50)

Mycophenolate mofetil

 Yes

76.40 (54.52–85.49)

0.073

78.10 (68.75–87.50)

0.471

75 (58.30–91.60)

0.139

83.30 (75–100)

0.098

100 (75–100)

0.778

75 (50–83.30)

0.228

75 (55.15–86.50)

0.173

75 (41.25–90)

0.008^***

68.77 (51.56–81.25)

0.169

 No

81.49 (67.93–88.35)

78.11 (68.75–90.60)

78.10 (68.75–87.50)

91.60 (75–100)

100 (75–100)

75 (43.70–91.67)

79.16 (66.60–91.64)

87.50 (75–100)

75 (60.62–87.50)

Azathioprine

 Yes

78.16 (65.44–89.70)

0.573

78.10 (65.60–90.62)

0.866

91.60 (75–91.70)

0.072

100 (75–100)

0.351

100 (75–100)

0.334

75 (33.33–91.60)

0.845

75 (58.30–87.50)

0.275

90 (70–95)

0.299

75 (56.25–87.50)

0.744

 No

80 (65.53–86.77)

78.10 (68.75–89.05)

75 (66.60–90.62)

83.3 (75–100)

100 (75–100)

75 (50–91.60)

79.10 (62.50–89.55)

80 (65–100)

75 (56.25–84.62)

Methotrexate

 Yes

64.73 (51.56–86.28)

0.257

68.70 (60.93–87.50)

0.179

66.85 (37.52–81.25)

0,175

75 (64.52–93.70)

0.221

77 (18.75–100)

0.136

79.15 (37.45–100)

0.629

77.05 (36.45–87.50)

0.866

77.5 (52.50–85)

0.399

59.35 (40.62–82.77)

0.254

 No

80.18 (65.72–87.09)

78.10 (68.75–90.60)

75 (66.69–91.60)

91.60 (75–100)

100 (75–100)

75 (50–91.60)

79.05 (61.45–87.50)

85 (65–100)

75 (56.25–87.50)

Cyclosporine

 Yes

88.16 (73.50–89.24)

0.212

78.11 (73.37–89.84)

0.660

79.15 (75–95.82)

0.500

91.65 (77.07–100)

0.521

100 (81.25–100)

0.457

83.30 (39.57–95.82)

0.522

83.33 (75–93.94)

0.426

85 (76.25–90)

0.963

81.25 (75–87.50)

0.181

 No

79.19 (65.41–86.62)

78.10 (68.75–89.82)

75 (66.61–91.60)

87.65 (75–100)

100 (75–100)

75 (50–91.60)

79.05 (58.30–87.50)

85 (65–100)

75 (56.25–86.06)

Organ involvement^*

Musculoskeletal

 Yes

80.18 (65.61–87.13)

0.387

78.10 (68.70–90.60)

0.738

75 (66.64–91.60)

0.917

83.31 (75–100)

0.727

100 (75–100)

0.030^***

75 (50–91.60)

0.212

79.10 (5.30–91.60)

0.375

82.50 (65–100)

0.680

75 (56.25–87.50)

0.438

 No

73.70 (62.93–84.29)

82.77 (65.55–87.12)

75 (70.82–93.74)

91.60 (75–100)

75 (43.75–100)

62.50 (25–79.15)

75 (68.72–80.19)

87.50 (78–95)

66.25 (54.65–76.56)

Mucocutaneous

 Yes

79.75 (65.42–86.94)

0.519

78.10 (68.75–89.05)

0.766

75 (66.68–91.60)

0.706

91.60 (75–100)

0.556

100 (75–100)

0.821

75 (50–83.30)

0.288

79.10 (58.30–87.50)

0.305

80 (65–95)

0.156

75 (56.25–84.62)

0.794

 No

81.51 (68.98–92.31)

75 (62.50–90.62)

75 (58.30–100)

83.30 (75–100)

87.50 (75–100)

91.60 (33.30–100)

75 (75–100)

95 (75–100)

75 (50–87.50)

Renal

 Yes

81.34 (70.80–87.17)

0.431

78.10 (68.75–90.60)

0.957

75 (75–91.66)

0.275

83.30 (75–100)

0.923

100 (75–100)

0.121

75 (56.40–91.60)

0.836

79.13 (73.95–88.52_

0.630

82.50 (68.75–95)

0.743

75 (56.25–87.50)

0.463

 No

78.39 (65.06–86.87)

78.11 (68.75–88.27)

75 (58.60–91.60)

91.60 (75–100)

100 (75–100)

75 (41.60–91.61)

77 (54.14–88.52)

85 (65–100)

82.50 (68.75–95)

Hematology

 Yes

83.50 (65.22–88.79)

0.577

75 (65.60–87.50)

0.637

83.30 (75–91.70)

0.227

91.60 (75–100)

0.791

100 (75–100)

0.638

75 (33.33–91.60)

0.685

75 (58.33–87.50)

0.221

88 (70–95)

0.637

70 (56.26–87.50)

0.863

 No

78.58 (65.56–85.88)

78.10 (68.75–90.60)

75 (66.60–83.30)

83.33 (75–100)

100 (75–100)

75 (50–91.60)

79.16 (60.40–91.63)

80 (65–100)

75 (56.25–81.25)

Neuropsychiatric

 Yes

80 (50,49–88,28)

0,452

75 (65.60–90.60)

0.523

83.30 (50–91.60)

0.858

83.30 (66.60–100)

0.365

87.50 (37.50–100)

0.086

75 (41.60–91.60)

0.732

75 (45.80–91.60)

0.190

85 (55–100)

0.972

70 (56.25–87.50)

0.884

 No

79,75 (67,07–86,77)

78.10 (68.75–89.05)

75 (66.68–91.60)

91.60 (75–100)

100 (75–100)

75 (50–91.60)

79.16 (67.05–87.50)

85 (67.50–97.50)

75 (56.25–84.62)

Education level^*

 Primary

81.51 (59.05–91.16)

0.160

81.20 (65.62–90.61)

0.806

83.30 (66.65–95.93)

0.245

91.60 (75–100)

0.690

100 (75–100)

0.978

75 (70.80–91.65)

0.210

83.30 (75–93.70)

0.110

90 (72.50–100)

0.083

81.20 (65.62–93.72)

0.138

 Secondary

77.48 (61.23–85.83)

78.10 (68.70–90.60)

75 (58.60–83.30)

83.50 (75–100)

100 (75–100)

75 (41.60–83.30)

75 (48.95–84.37)

77.50 (48.75–95)

68.72 (50–81.37)

 Tertiary

81.05 (66.83–89.02)

78.10 (70.27–87.50)

83.30 (70.85–91.63)

83.33 (75–100)

100 (75–100)

75 (58.30–93.2)

75 (67.05–91.60)

90 (72.50–100)

75 (61–87.50)