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Table 2 Clinical outcomes in eRA cohort after 24 weeks of treatment

From: Transitional and CD21 PD-1+ B cells are associated with remission in early rheumatoid arthritis

 

eRA all treatment arms

(n = 70)

MTX + prednisolone

(n = 12)

MTX + anti-TNF

(n = 22)

MTX + CTLA4-Ig

(n = 17)

MTX + anti-IL-6R

(n = 19)

p-value

CDAI Remission, n (%)

28 (40)

2 (16.7)

8 (36.4)

10 (59)

8 (42)

0.16b

CDAIa

3.8 (0.1–28.3)

5 (1.6–15.5)

4.2 (0.2–19.2)

2.3 (0.1–28.3)

3.3 (0.1–18.5)

0.26c

TJC 28a

0.5 (0–19)

1 (0–11)

0 (0–4)

0 (0–19)

1 (0–15)

0.26c

SJC 28a

0.0 (0–6)

0 (0–1)

0 (0–6)

0 (0–6)

0 (0–3)

0.61c

PGAa

14.5 (0–92)

19 (2–62)

14.5 (2–92)

9 (0–60)

10 (0–76)

0.099c

EGAa

6.5 (0–40)

11 (1–34)

7.5 (0–40)

5 (0–24)

4 (0–22)

0.33c

  1. aMedian and range
  2. bDifference between treatment arms, Fisher’s exact test
  3. cDifference between treatment arms, Kruskal-Wallis test
  4. eRA: early Rheumatoid Arthritis; CDAI: Clinical Disease Activity Index; SJC: Swollen Joint Count; TJC: Tender Joint Count; PGA: Patient Global Assessment; EGA: Evaluator Global Assessment