Table 4 The performance of intervention thresholds for treating glucocorticoid-induced osteoporosis based on different guidelines against actual fragility fractures. Result reported in number (95% confidence interval)
Guidelines | Sensitivity | Specificity | PPV | NPV | Accuracy | AUC |
|---|---|---|---|---|---|---|
ACR 2022 | 100 (89.1–100) | 3.1 (1.14–6.61) | 14.6 (10.2–19.9) | 100 (54.1–100) | 16.8* (12.2–22.3) | 0.590 (0.494–0.685) |
Korean 2018 | 100 (89.1–100) | 17.5 (12.5–23.6) | 16.7 (11.7–22.7) | 100 (89.7–100) | 29.2* (23.4–35.6) | 0.587 (0.491–0.683) |
Malaysia 2015 | 78.1 (60–90.7) | 62.9 (55.7–69.7) | 25.8 (17.4–35.7) | 94.6 (89.1–97.8) | 65 (58.4–71.2) | 0.719 (0.627–0.810) |
Belgian 2022 | 93.8 (79.2–99.2) | 14.4 (9.8–20.2) | 15.3 (10.6–21.1) | 93.3 (77.9–99.2) | 25.7* (20.1–31.9) | 0.558 (0.457–0.559) |
TOPF2021 | 93.8 (79.2–99.2) | 43.8 (36.7–51.1) | 21.6 (15.1–29.4) | 97.7 (91.9–99.7) | 50.9 (44.2–57.6) | 0.704 (0.625–0.784) |
Japan 2023 | 100 (89.1–100) | 24.2 (18.4–30.9) | 17.9 (12.6–24.3) | 100 (92.5–100) | 35* (28.8–41.6) | 0.621 (0.530–0.711) |