Fig. 4

Kaplan-Meier Curves for Treatment Outcomes Stratified by Timing of Tacrolimus Introduction After TNF Inhibitor Discontinuation. Kaplan-Meier curves comparing the time to clinical outcomes between the initial Combi group (n = 25), the subsequent Combi group (n = 19), and the Mono group (n = 91). The initial Combi group consisted of maintenance treatment episodes with methotrexate-tacrolimus combination therapy initiated after the first TNF inhibitor discontinuation, while the subsequent Combi group received combination therapy after the second or subsequent TNF inhibitor discontinuations. Tick marks indicate censored data. P-values were calculated using the log-rank test, and pairwise comparisons between the groups were performed using the Bonferroni method to adjust for multiple comparisons. Refer to the legend of Fig. 2 for abbreviations