Fig. 7

Serum creatinine levels over time, stratified by tacrolimus use. These scatter plots depict serum creatinine values over time for all participants stratified by tacrolimus use. For this analysis, the observations where tacrolimus had been used consecutively were consolidated: 44 lines with tacrolimus treatment (median observation period: 8.6 years; interquartile range: 5.6–10.4; 1,847 data points) and 91 lines without prior and current tacrolimus treatment (7.5; 4.8–10.3; 3,985) were compared. The baseline for the tacrolimus-treated or non-tacrolimus-treated groups was determined using the earliest time points measured immediately around the start of tacrolimus or TNF inhibitor treatment, respectively