Table 3 Summary of treatment failure events per maintenance treatment line

Number of treatment failure events

65

(67.7%)

22

(43.1%)

Details of treatment failure

 Initiation of Index drugs for rheumatoid arthritis flares

61

(93.8%)

18

(81.8%)

  Resuming the TNF inhibitor

49

(75.4%)

15

(68.2%)

  Initiation of glucocorticoids

3

(4.6%) ¹

2

(9.1%)

  Initiation of leflunomide

3

(4.6%)

0

(0.0%)

  Initiation of glucocorticoids and leflunomide

0

(0.0%)

1

(4.5%)

  Initiation of tacrolimus

6

(9.2%) ²

-

 Adverse events with discontinuation of treatment

4

(6.2%)

4

(18.2%)

  Lymphoproliferative disorders

3

(4.6%)

1

(4.5%)

  Other neoplasm

0

(0.0%)

1

(4.5%) ³

  Deterioration of renal function

0

(0.0%)

1

(4.5%) ⁴

  Sudden death

0

(0.0%)

1

(4.5%)

  Other

1

(1.5%) ⁵

0

(0.0%)