Fig. 1

Identification of circulating exosomes. (a, b) Size and concentration of circulating exosomes from patients with rheumatoid arthritis (RA) and healthy controls (HCs) analyzed by nanoparticle tracking analysis (NTA), respectively; (c, d) Circulating exosomes of patients with RA and HCs verified by transmission electron microscopy (TEM), respectively; scale bar: 200Â nm. (e) Specific exosome markers CD9, CD63 and HSP70 analyzed by Western blotting