Fig. 2

Screening of differentially expressed circulating exomiRNAs in patients with RA and HCs. (a) Volcano map of differentially expressed circulating exomiRNAs in the sequencing group; Green: downregulated exomiRNAs in the sequencing group; Gray: not significant. (b) Heatmap of differentially expressed circulating exomiRNAs. (c–m) qRT-PCR detected the expression of 11 candidate circulating exomiRNAs in the selected group. The values are normalized to Cel-miRNA-39-3p and shown on a log10 scale on the 𝑦-axis. All data are represented as the mean ± SD. ***p < 0.001, ** p < 0.01, * p < 0.05