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Fig. 4 | BMC Rheumatology

Fig. 4

From: Circulating exo-miRNA-27a-5p is a novel biomarker of the tofacitinib treatment response in rheumatoid arthritis

Fig. 4

Enrichment analyses of the biological functions of exomiRNAs. (a) Gene ontology (GO) annotation of the biological processes (BPs) and molecular functions (MFs) for targets of exomiRNAs. (b) Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of possible signaling pathways of exomiRNAs. (c) Enrichment analysis network between target genes of exomiRNAs and pathways. (d) PPI network showing the 133 exomiRNA targets. (e) MCODE analysis showing the network of the 9 hub genes. (f) Regulatory network between exomiRNAs and 9 hub genes. The brown circles represent hub genes and the blue triangles represent exomiRNAs

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