Table 3 Factors associated with depression (PHQ-9 ≥ 10) and positive GAD screen (GAD-7 ≥ 10)

Age

41.2 (15.4)

40.1 (15.2)

0.778

39.6 (15.6)

41.8 (14.8)

0.596

Age at SLE diagnosis

27.9 (11.4)

30.1 (13.4)

0.499

27.6 (11.8)

30.3 (12.9)

0.423

Married

25 (64.1)

16 (72.7)

0.491

26 (60.5)

11 (61.1)

0.796

Unemployed

22 (56.4)

7 (31.8)

0.065

23 (53.5)

6 (33.3)

0.094

White collar

9 (23.1)

6 (27.3)

0.472

9 (20.9)

6 (33.3)

0.341

BMI

27.4 (5.6)

25.6 (4.2)

0.200

26.8 (5.4)

26.1 (4.5)

0.625

PHQ-9 ≥ 10

-

-

-

8 (18.6)

14 (77.8)

< 0.001

GAD-7 ≥ 10

4 (10.3)

14 (35.9)

< 0.001

-

-

-

 Fibromyalgia

6 (15.4)

14 (63.6)

< 0.001

8 (18.6)

12 (66.7)

< 0.001

MSPSS

68.0 (12.3)

67.9 (11.7)

0.979

68.3 (8.8)

67.2 (17.2)

0.746

SLEDAI

8.5 (9.7)

6.7 (8.0)

0.485

8.8 (9.8)

4.6 (5.8)

0.054

SF-12

 MCS-12

51.9 (3.5)

52.0 (3.6)

0.929

52.2 (3.7)

51.1 (2.3)

0.251

 PCS-12

44.0 (8.8)

37.3 (10.2)

0.009

45.3 (8.1)

34.2 (9.1)

< 0.001

 Constitutional symptoms

27 (69.2)

13 (59.1)

0.742

28 (65.1)

12 (66.7)

0.907

Organ involvement

 Kidney

14 (35.9)

5 (22.7)

0.361

13 (30.2)

6 (33.3)

0.704

 Eye

4 (10.3)

6 (27.3)

0.069

6 (14.0)

4 (22.2)

0.370

 Heart

25 (64.1)

10 (45.5)

0.222

24 (55.8)

11 (61.1)

0.432

 Mucocutaneous

32 (82.1)

19 (86.4)

0.501

36 (86.0)

15 (83.3)

0.298

 Joints

36 (92.3)

16 (72.7)

0.166

36 (83.7)

16 (88.9)

0.604

 Hematological

34 (87.2)

17 (77.3)

0.817

34 (83.7)

17 (94.4)

0.49

 Vascular

20 (51.3)

18 (81.8)

0.011

28 (67.4)

10 (61.)

0.929

 Gastrointestinal

2 (5.1)

1 (4.5)

0.696

2 (4.7)

1 (5.6)

0.600

 Pulmonary

13 (33.3)

6 (27.3)

0.894

13 (30.2)

6 (33.3)

0.839

 Neuropsychiatry

5 (12.8)

4 (18.2)

0.372

6 (14.0)

3 (16.7)

0.718

 Osteoporosis

6 (15.4)

3 (13.6)

0.506

4 (9.3)

5 27.8)

0.066

 Osteopenia

11 (28.2)

6 (27.3)

0.676

14 (32.6)

3 (16.7)

0.131

Treatment

 Glucocorticoids

27 (59.2)

18 (81.8)

0.283

30 (69.8)

15 (83.3)

0.188

 Mycophenolate

14 (35.9)

10 (45.5)

0.463

16 (37.2)

8 (44.4)

0.667

 Hydroxychloroquine

30 (76.9)

19 (86.4)

0.295

33 (76.7)

16 (88.9)

0.532

 Tacrolimus

6 (15.4)

1 (4.5)

0.200

5 (11.6)

2 (11.1)

0.647

 Azathioprine

14 (35.9)

6 (27.3)

0.346

14 (34.9)

6 (38.9)

0.833

 Methotrexate

3 (7.7)

2 (9.1)

0.599

4 (9.3)

1 (5.6)

0.521

 Leflunomide

0 (0)

1 (4.5)

0.361

0 (0)

1 (5.6)

0.302

 Cyclosporine

1 (2.6)

0 (0)

0.639

1 (2.3)

0 (0)

0.698

Laboratory results

 ESR

38.7 (26.1)

30.3 (25.0)

0.239

33.8 (24.7)

39.6 (28.2)

0.427

 CRP

4.1 (6.0)

11.0 (14.9)

0.016

7.2 (12.3)

3.6 (3.8)

0.229

 Creatinine

0.84 (0.34)

0.81 (0.49)

0.819

0.85 (0.35)

0.78 (0.47)

0.540

 Lymphocytes

1.7 (0.93)

1.8 (0.85)

0.625

1.9 (1.0)

1.7 (0.74)

0.418

 Neutrophils

3.6 (1.9)

3.6 (1.8)

0.935

4.2 (2.8)

3.1 (1.3)

0.098

 Platelets

278.3 (94.1)

260.1 (77.6)

0.460

273.2 (95.7)

259.8 (71.2)

0.594

 Hemoglobin

11.8 (1.5)

11.9 (1.6)

0.820

12.0 (1.6)

11.5 (1.4)

0.211

 NLR

2.1 (0.99)

3.5 (3.8)

0.040

2.7 (2.9)

2.0 (1.2)

0.356

 PLR

191 (112.5)

171.6 (109.9)

0.515

183.4 (125.5)

174.4 (70.4)

0.779

 Ds-DNA

15 (38.5)

10 (45.5)

0.283

15 (34.9)

10 (55.6)

0.134

 Low C3

10 (25.6)

5 (22.7)

0.609

10 (23.6)

5 (27.8)

0.859

 Low C4

5 (12.8)

2 (9.1)

0.557

5 (11.6)

2 (11.1)

0.595