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  1. Artificial intelligence (AI) tools, particularly Large Language Models (LLMs), are revolutionizing medical practice, including rheumatology. However, their diagnostic capabilities remain underexplored in the A...

    Authors: Yannick Laurent Tchenadoyo Bayala, Wendlassida Joelle Stéphanie Zabsonré/Tiendrebeogo, Dieu-Donné Ouedraogo, Fulgence Kaboré, Charles Sougué, Aristide Relwendé Yameogo, Wendlassida Martin Nacanabo, Ismael Ayouba Tinni, Aboubakar Ouedraogo and Yamyellé Enselme Zongo
    Citation: BMC Rheumatology 2025 9:54
  2. Giant cell arteritis (GCA) is a large vessel vasculitis characterized by granulomatous inflammation classically affecting the carotid artery branches. GCA most often presents with one or more classic clinical ...

    Authors: James Gow and David Roofeh
    Citation: BMC Rheumatology 2025 9:53
  3. Data regarding the relationship between socioeconomic status (SES) and incidence of Giant Cell Arteritis (GCA) is conflicting. No previous studies have explored whether SES influences the likelihood of undergo...

    Authors: Suellen Anne Lyne, Susan Lester, Oscar Kenneth Russell, Carlee Deanne, Kathryn Dyer, Jem Ninan, Ernst Michael Shanahan and Catherine Louise Hill
    Citation: BMC Rheumatology 2025 9:52
  4. Osteoarthritis (OA) is a chronic disease primarily affecting older adults, mainly impacting the hip and knee joints. The increasing prevalence of OA contributes to rising healthcare demands and costs. Current ...

    Authors: Britt van Dongen, Amber Ronteltap, Bastiaan Cijs, Corelien Kloek, Catherine Bolman and Rik Crutzen
    Citation: BMC Rheumatology 2025 9:51
  5. Dermatomyositis (DM) is an immune-mediated myopathy characterized by proximal muscle weakness, inflammation, and cutaneous manifestations. Up to 25% of DM patients have an associated malignancy. Those with can...

    Authors: Sehreen Mumtaz, Jordan Phillipps, Megan M. Sullivan, Maximiliano Diaz-Menindez, Benjamin Wang, Vikas Majithia, Emily Craver and Florentina Berianu
    Citation: BMC Rheumatology 2025 9:50
  6. Effective biological markers able to monitor the response of Janus kinase inhibitor (JAKi) are lacking. Exosomal microRNAs (exomiRNAs) can alter their expression during treatment and are ideal biomarkers for t...

    Authors: Jiwei Zhao, Tianjun Zhu, Qiu Liao, Jijia Sun and Fuqun Liu
    Citation: BMC Rheumatology 2025 9:49
  7. Professionals in health and social care are challenged by the complexity and fragmentation across primary and secondary levels of care. To study coherent rehabilitation pathways, we focused on people with infl...

    Authors: Helle Feddersen, Camilla Vestergaard Aarøe, Jens Søndergaard, Lena Andersen, Bettina Munksgaard and Jette Primdahl
    Citation: BMC Rheumatology 2025 9:48
  8. The C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index is a novel biomarker reflecting inflammation, nutrition, and immune status, and its potential clinical significance and prognostic role in patients...

    Authors: Jialin Zhang, Yanhua Lin, Jingyan Zeng, Guihu Luo, Pan Liao, Qianyun Chen, Han Zhong, Simei Liang, Cailiu Zhou, Bin Yang and Xing Li
    Citation: BMC Rheumatology 2025 9:47
  9. Immune-mediated necrotizing myopathy (IMNM) and dermatomyositis (DM) are characterized by weakness, hyperCKemia, associated autoantibodies, and varying extramuscular manifestations. Muscle MRI, currently subor...

    Authors: Anson W. Wilks, Kiana M. Vakil-Gilani, William D. Rooney, Dongseok Choi, Daniela Ghetie and Nizar Chahin
    Citation: BMC Rheumatology 2025 9:46
  10. Early initiation of effective treatment is associated with positive long-term prognosis for patients with rheumatoid arthritis (RA). Currently, there are no biomarkers in clinical use to predict treatment resp...

    Authors: Sarah McGrath, Boel Sundbeck, Katrin Thorarinsdottir, Charlotte A. Jonsson, Alessandro Camponeschi, Monica Leu Agelii, Anna-Karin H. Ekwall, Merete Lund Hetland, Mikkel Østergaard, Till Uhlig, Michael Nurmohamed, Jon Lampa, Dan Nordström, Kim Hørslev-Petersen, Bjorn Gudbjornsson, Gerdur Gröndal…
    Citation: BMC Rheumatology 2025 9:45
  11. Fatigue is a prominent symptom in patients with psoriatic arthritis (PsA). There was a wide variety of statistics previously reported on fatigue prevalence in patients. This systematic review examined the curr...

    Authors: Haoming Tang, Tricia Li Ting Chew and Warren Fong
    Citation: BMC Rheumatology 2025 9:44
  12. This study examines the influence of pharmacological treatments on foot functionality in patients with rheumatoid arthritis over a five-year period. A longitudinal analysis categorized patients into different ...

    Authors: Maria Gamez-Guijarro, Andres Reinoso-Cobo, Manuel Pardo-Rios, Ana-Belen Ortega-Avila, Laura Ramos-Petersen, Gabriel Gijon-Nogueron and Eva Lopezosa-Reca
    Citation: BMC Rheumatology 2025 9:43
  13. IgA vasculitis is a predominantly pediatric autoimmune disease characterized by IgA deposit in small vessels. Chronic myelomonocytic leukemia (CMML) is a rare hematological malignancy classified within myelody...

    Authors: Bénédicte Rouvière, Francois Chasset, Noémie Abisror, Pierre Hirsch, Olivier Fain and Arsène Mékinian
    Citation: BMC Rheumatology 2025 9:42
  14. The role of preceding infections in the development of reactive arthritis (ReA) is well known but is less studied in association with other inflammatory arthritides. Therefore, in 1979-80 we screened for infec...

    Authors: Riitta Tuompo, Timo Hannu, Leena Paimela, Hannu Kautiainen, Marjatta Leirisalo-Repo and Riitta Koivuniemi
    Citation: BMC Rheumatology 2025 9:41
  15. Childhood-onset rheumatic diseases, such as juvenile idiopathic arthritis, juvenile-onset lupus and juvenile dermatomyositis, appear to be associated with an increased risk of comorbidities in adulthood compar...

    Authors: Sab Siddiq, Jenny Sammy Ainsworth, Clare E. Pain, Eve M.D. Smith, Sizheng Steven Zhao, David M. Hughes and Liza J. McCann
    Citation: BMC Rheumatology 2025 9:40
  16. This study evaluates the long-term effectiveness and safety of methotrexate-tacrolimus combination therapy compared to methotrexate monotherapy in maintaining successful tumor necrosis factor (TNF) inhibitor d...

    Authors: Taio Naniwa and Mikiko Kajiura
    Citation: BMC Rheumatology 2025 9:39
  17. Glucocorticoid-induced osteoporosis (GIO) is the most common drug-induced osteoporosis. Early detection and treatment may decrease the fragility fractures. Several GIO guidelines exist, although they vary in r...

    Authors: Kanchalee Puksun, Chatlert Pongchaiyakul, Rattapol Pakchotanon, Pongthorn Narongroeknawin, Pornsawan Leosuthamas, Thunyawarin Arunthanachaikul and Sumapa Chaiamnuay
    Citation: BMC Rheumatology 2025 9:38
  18. Cognitive impairment among patients with systemic lupus erythematosus (SLE) can significantly impact quality of life (QoL). This study aimed to determine the prevalence of cognitive impairment in SLE patients ...

    Authors: Mir’atul Ginayah, Alvina Widhani, Riwanti Estiasari, Sukamto Koesnoe, Suzy Maria, Raden Mas Suryo Anggoro Kusumo Wibowo, Pradana Soewondo, Hamzah Shatri, Pukovisa Prawiroharjo, Nina Kemala Sari and Aulia Rizka
    Citation: BMC Rheumatology 2025 9:37
  19. Early diagnosis and modern treatment have changed everyday life of patients with rheumatoid arthritis (RA). However, symptoms are still pronounced several years after diagnosis. The aim of this study is theref...

    Authors: Maria Bergström, Åsa Larsson Ranada, Annette Sverker, Ingrid Thyberg and Mathilda Björk
    Citation: BMC Rheumatology 2025 9:35
  20. To analyze the status and correlation factors of fatigue in patients with ankylosing spondylitis (AS), and provide a reference for improving the fatigue status of patients with AS.

    Authors: Tiantian Sun, Kun Yang, Yuening Chen, Zhaoyang Geng, Xinning Qu, Qing Yu and Hongxiao Liu
    Citation: BMC Rheumatology 2025 9:34
  21. Fibromyalgia is currently diagnosed under the 2016 research criteria, a combination of the 2010 and 2011 criteria revisions. The current guidelines have led to ongoing misdiagnosis issues dating back to the cr...

    Authors: Anthony Rubano, Michael R. Jiroutek and Susan Avila Misciagno
    Citation: BMC Rheumatology 2025 9:33
  22. Osteoarthritis (OA), a prevalent and disabling condition, significantly burdens individuals and healthcare systems worldwide. It is characterized by joint pain, stiffness, and structural changes in cartilage, ...

    Authors: Gabriel Gijon-Nogueron, Peter Balint, Anastas Batalov, Predrag Ostojic, Nico Sollmann, Marienke van Middelkoop, Rintje Agricola, Josefine E. Naili, Darko Milovanovic, Stanislava Popova, Maria Kazakova, Sylvia Nuernberger, Cecilia Aulin, Rositsa Karalilova and Yves Henrotin
    Citation: BMC Rheumatology 2025 9:32
  23. Timely, high-quality care is critical to rheumatoid arthritis (RA) management. In Alberta, thousands of individuals with RA are waiting for care due to the resource-intensive nature of lifelong follow-ups and ...

    Authors: Manuel Ester, Krista White, Kiran Dhiman, Saania Zafar, Shakeel Subdar, Gabrielle L. Zimmermann, Alison M. Hoens, Sarah L. Manske, Glen Hazlewood, Diane Lacaille, Megan R. W. Barber, Niki Panich, Michelle Jung, Mark G. Perry, Marinka Twilt, Karen L. Then…
    Citation: BMC Rheumatology 2025 9:31
  24. Pregnancy may have a beneficial effect on disease activity in rheumatoid arthritis (RA) but the evidence is more conflicting in spondyloarthritis (SpA). The aim of this study was to analyse disease activity an...

    Authors: Marion Couderc, Céline Lambert, Sabrina Hamroun, Denis Gallot, Nathalie Costedoat-Chalumeau, Laure Gossec, Gaëlle Guettrot-Imbert, Veronique Le Guern, Christophe Richez, Martin Soubrier and Anna Molto
    Citation: BMC Rheumatology 2025 9:30
  25. Spondyloarthritis (SpA) exhibits predominantly musculoskeletal symptoms but also significant gastrointestinal (GI) and psychological manifestations. Subclinical gut inflammation is common in SpA, with frequent...

    Authors: Ángelo Arzuaga-Hernández, Omar-Javier Calixto, Oscar Gómez, Juliette De Ávila, Julián Andrés Sucerquia-Quintero, Juan Manuel Bello-Gualtero, Cristian Flórez-Sarmiento, Wilson Bautista-Molano and Consuelo Romero-Sánchez
    Citation: BMC Rheumatology 2025 9:28
  26. The higher mortality rates in patients with Systemic sclerosis (SSc) are related to SSc activity, cardiovascular disease, and neoplasms, among other factors. Our objective was to assess the impact of solid org...

    Authors: María Martínez-Urbistondo, Antonio González-Guzmán, Román Fernández-Guitián, Xiomara Patricia Blanco-Valencia, Jorge Esteban-Sampedro, Mario Martín-Portugués, Pedro Durán-del Campo, Pablo Tutor, Susana Mellor-Pita, Alfonso Ortega-de la Puente, Marina de la Cruz-Echeandía and Víctor Moreno-Torres
    Citation: BMC Rheumatology 2025 9:27
  27. Systemic Lupus erythematosus (SLE) is an autoimmune disorder in which females are affected more commonly than males. In addition to the physical burden of the disease, patients with SLE are at higher risk of p...

    Authors: Fatima Alnaimat, Omar Hamdan, Tala Natsheh, Raghad Bani Hamad, Zain Abu Amrieh, Dania Ahmad, Mahdi H. Mohammed and Nada Al-Awamleh
    Citation: BMC Rheumatology 2025 9:26
  28. Pulmonary hypertension (PH) is the leading cause of death among patients with systemic sclerosis (SSc). Recently, early therapeutic intervention to improve the prognosis was suggested, and the definition of PH...

    Authors: Shuhei Takeyama, Hironari Hanaoka, Akiyoshi Hashimoto, Yusho Ishii, Yuka Shimizu, Toshiharu Takeuchi, Shuhei Shimoyama, Masataka Kuwana, Tomoaki Higuchi, Masaru Yoshimura, Hiroshi Kataoka, Yuko Shirota, Kazufumi Okada, Yoichi M. Ito, Ryo Hisada, Kazuro Kamada…
    Citation: BMC Rheumatology 2025 9:25
  29. To determine whether the presence of conventional radiography (CR)-detected osteophytes is associated with focal thickening of the hyaline cartilage by ultrasound (US) in the same area of the metacarpal head i...

    Authors: Edoardo Cipolletta, Gianluca Smerilli, Riccardo Mirza Mashadi, Peter Mandl and Emilio Filippucci
    Citation: BMC Rheumatology 2025 9:24
  30. Dermatomyositis (DM) is a rare and progressive immune-mediated disease with no cure and significant patient burden that encompasses physical, mental, and financial impacts. Patients experience debilitating sym...

    Authors: Lisa Christopher-Stine, Julie J. Paik, Alexandra S. Goriounova and Paul N. Mudd Jr.
    Citation: BMC Rheumatology 2025 9:23
  31. Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by synovial inflammation, cartilage, and bone destruction. Several studies have shown that leptin plays an important role in the pathoph...

    Authors: Mostafa Kaboli, Manouchehr Nakhjavani, Soghra Rabizadeh, Marsa Gholamzadeh and Seyed Reza Najafizadeh
    Citation: BMC Rheumatology 2025 9:22
  32. IgG4-related disease (IgG4-RD) is a systemic fibro-inflammatory condition characterized by elevated IgG4 serum levels and tissue infiltration by IgG4-positive plasma cells. While often presenting with organ-sp...

    Authors: Faizan Bashir, Moiza Bashir, Moniza Rafiq, Ali Jafer and Saide Honarmand
    Citation: BMC Rheumatology 2025 9:20
  33. Physical activity (PA), including regular exercise, is essential for the successful management of axial spondyloarthritis (axSpA). To promote a physically active lifestyle, a digital training diary (Trainingslog)...

    Authors: Neva Pfyl, Lea Ettlin, Karin Niedermann and Anne-Kathrin Rausch
    Citation: BMC Rheumatology 2025 9:18
  34. We sought to assess the feasibility of a stepped-wedge cluster-randomised trial testing the effectiveness of a complex mHealth intervention called REMORA: a co-designed smartphone app enabling daily, weekly an...

    Authors: Katie L. Druce, Yumna Masood, Helen Chadwick, Sarah Skyrme, Deb Griffiths-Jones, Ramiro D. Bravo Santisteban, Peter Bower, Jill Firth, Charlotte A. Sharp, Christopher J. Armitage, Dawn Dowding, John McBeth, Caroline Sanders, William G. Dixon and Sabine N. van der Veer
    Citation: BMC Rheumatology 2025 9:17
  35. Psoriatic arthritis (PsA) is a chronic, inflammatory rheumatic disease. We aim to describe the characteristics of PsA patients and examine factors affecting their psychological and physical well-being.

    Authors: Fatima Alnaimat, Khaldoon Alawneh, Ayman AbuHelal, Omar Hamdan, Almothana Alelaimat, Manal Al Mashaleh, Ausaylah Burqan, Wala Rababah, Rabaa Rababah and Marwan Adwan
    Citation: BMC Rheumatology 2025 9:16
  36. Systemic sclerosis (SSc) is associated with an increased risk of osteoporosis and fractures. The aim of this single-center cross-sectional study was to evaluate whether clinical phenotype and nailfold videocap...

    Authors: Irene Carlino, Antonella Al Refaie, Caterina Mondillo, Giulio Manzana, Stefania Bisogno, Serena Pierguidi, Matteo Capecchi, Stefano Gonnelli, Luigi Gennari and Carla Caffarelli
    Citation: BMC Rheumatology 2025 9:15
  37. Axial spondyloarthritis (axSpA) is an inflammatory rheumatic disease primarily affecting the sacroiliac joints and spine, leading to chronic pain, fatigue, and reduced mobility. The diagnostic delay for axSpA ...

    Authors: Susann May, Greta Nordmann, Franziska Gabb, Katharina Boy, Magali Wagner, Niklas Ohm, Hanna Labinsky, Johannes Knitza, Sebastian Kuhn, Martin Heinze, Martin Welcker and Felix Muehlensiepen
    Citation: BMC Rheumatology 2025 9:14
  38. In Colombia, there is a lack of recent real- word studies that provide information on the epidemiology and healthcare resource utilization (HCRU) of rheumatoid arthritis (RA) at national level.

    Authors: Daniel G. Fernández-Ávila, Monica Betancur, Amira Kronfly and Edwin Jáuregui
    Citation: BMC Rheumatology 2025 9:13
  39. Ankylosing Spondylitis (AS) presents a complex inflammatory condition with significant impact on patients’ lives. Despite advancements in understanding its pathogenesis, comprehensive elucidation remains elusi...

    Authors: Mohammadreza Chehrassan, Mohammadreza Shakeri, Farshad Nikouei, Saeed Sabbaghan, Behnam Sour, Ebrahim Ameri Mahabadi and Hasan Ghandhari
    Citation: BMC Rheumatology 2025 9:11
  40. Systemic lupus erythematosus (SLE) often presents with neuropsychiatric (NP) involvement, including cognitive impairment and depression. Past magnetic resonance imaging (MRI) research in SLE patients showed sm...

    Authors: Z. Makdad Najeeb, P. C. Sundgren, A. Jönsen, K. Zervides, J. Lätt, T. Salomonsson, J. Nystedt, P. Nilsson, A. Bengtsson, G. Kuchcinski and L. E. M. Wisse
    Citation: BMC Rheumatology 2025 9:10
  41. Avacopan, an oral C5a receptor antagonist, demonstrated efficacy as an alternative to glucocorticoid therapy in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in the phase...

    Authors: Genri Tagami, Makoto Yamaguchi, Hirokazu Sugiyama, Hiroshi Kinashi, Kentaro Imai, Keisuke Kamiya, Takayuki Katsuno, Takahiro Imaizumi, Shogo Banno, Yasuhiko Ito and Takuji Ishimoto
    Citation: BMC Rheumatology 2025 9:8
  42. Biologic (b) and targeted synthetic (ts) disease-modifying anti-rheumatic drugs (DMARDs) used in the management of rheumatoid arthritis (RA) target inflammatory pathways implicated in the pathogenesis of multi...

    Authors: Kate Tokareva, Alexander C. Peterson, Aaron Baraff, Sarah P. Chung, Jennifer Barton, Joshua F. Baker, Bryant R. England, Ted R. Mikuls, Nicholas L. Smith, David G. Coffey, Noel S. Weiss and Namrata Singh
    Citation: BMC Rheumatology 2025 9:7
  43. The anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody-positive dermatomyositis is known for its association with rapidly progressive interstitial lung disease (RP-ILD) and ulcerative skin le...

    Authors: Sai K. Koyoda, Fatema Ezzy, Dawn Wahezi, Anand Kumthekar, Xianhong Xie, Clement E. Tagoe and Bibi Ayesha
    Citation: BMC Rheumatology 2025 9:5

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